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IC261

A reversible, ATP-competitive inhibitor of casein kinase 1 (CK1)
Catalog #: 9669
SKU-Size Size Price Qty
9669-5 5 mg
$115.00
9669-25 25 mg
$425.00
More Sizes Get Quote

Product Details

Alternate Name (E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one; SU-5607
Appearance Yellow solid
CAS # 186611-52-9
Molecular Formula C₁₈H₁₇NO₄
Molecular Weight 311.34
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES COC1=CC(=C(C(=C1)OC)C=C2C3=CC=CC=C3NC2=O)OC
InChi InChI=1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)
InChi Key JBJYTZXCZDNOJW-UHFFFAOYSA-N
PubChem CID 3674
MDL Number MFCD00118156
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

IC261 is a reversible, ATP-competitive inhibitor of casein kinase 1 (CK1) (IC₅₀ = ~1 µM for CK1δ and CK1ɛ and 16 µM for CK1α). It is at least 100-fold less effective against PKA, p34cdc2, and p55fyn. IC261, at 1 µM, inhibits cytokinesis in primary mouse embryo fibroblasts. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.


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