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Iberdomide

A celebron modulator
Catalog #: B2284
SKU-Size Size Price Qty
B2284-1 1 mg
$75.00
B2284-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; CC-220
Appearance White to off-white solid
CAS # 1323403-33-3
Molecular Formula C₂₅H₂₇N₃O₅
Molecular Weight 449.5
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCOCC5
InChi InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1
InChi Key IXZOHGPZAQLIBH-NRFANRHFSA-N
PubChem CID 67335295
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Iberdomide is a celebron modulator that displays an IC₅₀ of 60 nM in TR-FRET cereblon binding assay. Cereblon is a substrate receptor in the CRL4 ubiquitin ligase complex. Iberdomide is potentially useful for the treatment of systemic lupus erythematosus (SLE), an autoimmune disease that is characterized by production of autoantibodies.


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