IACS-010759 (ab286961)
Key features and details
- A potent and selective Oxidative Phosphorylation Inhibitor
- CAS Number: 1570496-34-2
- Purity: >= 98%
Soluble in DMSO to 75 mM
- Form / State: Solid
Overview
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Product name
IACS-010759 -
Description
A potent and selective Oxidative Phosphorylation Inhibitor -
Biological description
A potent and selective Oxidative Phosphorylation Inhibitor (IC50 < 10 nM) with potential antineoplastic activity. IACS-010759 robustly inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis.
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Purity
>= 98% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called B2231 IACS-010759. B2231-1 is the same size as the 1 mg size of ab286961.
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CAS Number
1570496-34-2
Properties
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Chemical name
5-[5-methyl-1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-1,2,4-triazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
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Molecular weight
562.57 -
Molecular formula
C25H25F3N6O4S -
PubChem identifier
86711931 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in DMSO to 75 mM
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SMILES
CC1=NC(=NN1CC2=CC(=CC=C2)N3CCC(CC3)S(=O)(=O)C)C4=NC(=NO4)C5=CC=C(C=C5)OC(F)(F)F
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (1)
ab286961 has been referenced in 1 publication.
- Molina JR et al. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat Med 24:1036-1046 (2018). PubMed: 29892070