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Product Details
| Alternate Name | 5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1570496-34-2 |
| Molecular Formula | C₂₅H₂₅F₃N₆O₄S |
| Molecular Weight | 562.57 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | CC1=NC(=NN1CC2=CC(=CC=C2)N3CCC(CC3)S(=O)(=O)C)C4=NC(=NO4)C5=CC=C(C=C5)OC(F)(F)F |
| InChi | InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28)31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14,21H,10-13,15H2,1-2H3 |
| InChi Key | HWJWNWZJUYCGKV-UHFFFAOYSA-N |
| PubChem CID | 86711931 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
IACS-010759 is a potent and selective Oxidative Phosphorylation Inhibitor (IC₅₀ < 10 nM) with potential antineoplastic activity. IACS-010759 robustly inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis.
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