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I-CBP112

A selective CBP/EP300 bromodomain inhibitor
Catalog #: 9405
SKU-Size Size Price Qty
9405-1 1 mg
$75.00
9405-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one
Appearance White solid
CAS # 1640282-31-0
Molecular Formula C₂₇H₃₆N₂O₅
Molecular Weight 468.59
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES CCC(=O)N1CCOC2=C(C1)C=C(C=C2OCC3CCCN(C3)C)C4=CC(=C(C=C4)OC)OC
InChi InChI=1S/C27H36N2O5/c1-5-26(30)29-11-12-33-27-22(17-29)13-21(20-8-9-23(31-3)24(14-20)32-4)15-25(27)34-18-19-7-6-10-28(2)16-19/h8-9,13-15,19H,5-7,10-12,16-18H2,1-4H3/t19-/m0/s1
InChi Key YKNAKDFZAWQEEO-IBGZPJMESA-N
PubChem CID 90488984
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

I-CBP112 is a selective CBP/EP300 bromodomain inhibitor (IC₅₀ values of 170 nM, 170 nM, 151 nM and 625 nM for CREBBP(Alphascreen), CREBBP(BLI), CREBBP(ITC) and EP300(ITC),respectively). Selective for CBP and p300 over ATAD2, BAZ2B, BRD2(2), BRD4(1), PB1(5), PCAF, PHIP(2) and TIF1α bromodomains in a BLI assay.


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