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A BET bromodomain inhibitor
Catalog #: 2220
SKU-Size Size Price Qty
2220-1 1 mg
2220-5 5 mg
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Product Details

Alternate Name GSK1210151A
Appearance Beige to pale yellow solid
CAS # 1300031-49-5
Molecular Formula C₂₃H₂₁N₅O₃
Molecular Weight 415.44
Purity ≥98% by HPLC (≥99.5% optical purity)
Solubility DMSO (100 mM) or Ethanol (100 mM)
InChi InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
PubChem CID 52912189
MDL Number MFCD22124472
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A BET bromodomain inhibitor that interacts with BRD4 and BRD3 BET proteins and displaces them from chromatin; displays highefficacy against human and murine MLL-fusion leukemic cell lines, through the induction of early cell cycle arrest and apoptosis. The mode of action is, at least in part, due to suppressing the transcription of key genes (BCL2, C-MYC and CDK6) that are critical for MLL-fusion leukemia maintenance.

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