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Hypericin

A potent anticancer and antidepressant agent
Catalog #: 2526
SKU-Size Size Price Qty
2526-1 1 mg
$85.00
2526-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
Appearance Black solid
CAS # 548-04-9
Molecular Formula C₃₀H₁₆O₈
Molecular Weight 504.45
Purity ≥98% by HPLC
Solubility DMSO (~25 mg/ml) or EtOH (~10 mg/ml)
SMILES CC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O
InChi InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3
InChi Key BTXNYTINYBABQR-UHFFFAOYSA-N
PubChem CID 5281051
MDL Number MFCD00016683
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Isolated from Hypericum perforatum, St. John’s Wort. Hypericin has been shown to display antiviral and antiretroviral activity. A potent and selective inhibitor of protein kinase C (IC₅₀ = 3.4 µM). Also known to inhibit Casein Kinase II (CKII), MAP Kinase, Insulin R, EGFR, PI-3 Kinase. Displays antineoplastic and antitumor actitities. Most activities require light activation. Induces apoptosis in neuroblastoma cells at 1 µM or above (IC₅₀ = 0.1 µM at 29 mW/cm2 (tungsten light)). Used in photodynamic treatment of tumors and has been reported to be cytotoxic to some tumor cell lines when Hypericin is photoactivated.


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