Hygromycin B (ab286934)
Key features and details
- An antibiotic and a selection agent
- CAS Number: 31282-04-9
- Purity: >= 90%
H2O (~ 50 mg/ml)
- Form / State: Powder
Overview
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Product name
Hygromycin B -
Description
An antibiotic and a selection agent -
Alternative names
- Hygrovectine
- MFCD06795479
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Biological description
An aminoglycoside antibiotic produced by Streptomyces hygroscopicus that is routinely used as a selection agent for cells that contain hph or hyg Hygromycin resistant gene. Hygromycin B is thought to inhibit protein synthesis by strengthening the interaction of peptidyl-tRNA in the ribosomal acceptor (“A”) site thereby preventing translocation of by EF-2 (elongation Factor-2). Hygromycin B is effective on most bacteria, fungi and higher eukaryotes.
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Purity
>= 90% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 2589 Hygromycin B. 2589-1000 is the same size as the 1 g size of ab286934.
Protect from light and moisture.
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CAS Number
31282-04-9
Properties
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Chemical name
(3'R,3aS,4S,4'R,5'R,6R,6'R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
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Molecular weight
527.52 -
Molecular formula
C20H37N3O13 -
PubChem identifier
35766 -
Storage instructions
Shipped at 4°C. Store at +4°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
H2O (~ 50 mg/ml)
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Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN[C@H]1C[C@H]([C@@H]([C@H]([C@@H]1O)O[C@H]2[C@@H]3[C@H]([C@H]([C@H](O2)CO)O)OC4(O3)[C@@H]([C@@H]([C@H]([C@H](O4)[C@H](CO)N)O)O)O)O)N
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab286934 has been referenced in 1 publication.
- Brodersen DE et al. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell 103:1143-54 (2000). PubMed: 11163189