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Anti-HVEM / TNFRSF14 Antibody

Rabbit polyclonal unconjugated antibody to detect HVEM/TNFRSF14 in human amd mouse samples
Catalog #: A1084
$315.00

Product Details

Cat # +Size A1084-50
Size 50 µg
Antibody Target TNFRSF14
Alternate Name TNFRSF14 Antibody: TR2, ATAR, HVEA, HVEM, CD270, LIGHTR, UNQ329/PRO509, Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Accession # Q92956
Gene ID 8764
Appearance Colorless liquid
Species Reactivity Human and mouse
Application IHC, WB, IFC
Positive Control IHC, WB, IFC
Application & Usage IHC: 1 µg/ml; WB: 1-2 µg/ml; IFC: 10 µg/ml
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

TNFRSF14 Antibody: Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-κB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.


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