Product Details
| Cat # +Size | A1084-50 |
|---|---|
| Size | 50 µg |
| Antibody Target | TNFRSF14 |
| Alternate Name | TNFRSF14 Antibody: TR2, ATAR, HVEA, HVEM, CD270, LIGHTR, UNQ329/PRO509, Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Accession # | Q92956 |
| Gene ID | 8764 |
| Appearance | Colorless liquid |
| Species Reactivity | Human and mouse |
| Application | IHC, WB, IFC |
| Positive Control | IHC, WB, IFC |
| Application & Usage | IHC: 1 µg/ml; WB: 1-2 µg/ml; IFC: 10 µg/ml |
| Handling | The antibody solution should be gently mixed before use |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
TNFRSF14 Antibody: Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-κB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.
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