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(−)-Huperzine A

A potent and reversible inhibitor of acetylcholinesterase
Catalog #: B3095
SKU-Size Size Price Qty
B3095-5 5 mg
B3095-25 25 mg
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Product Details

Alternate Name Selagine, (1R,9R)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[,7]trideca-2(7),3,10-trien-5-one; 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)-
Appearance White crystalline powder
CAS # 102518-79-6
Molecular Formula C₁₅H₁₈N₂O
Molecular Weight 242.32
Purity ≥ 98%
Solubility ~20 mg/ml in DMSO
InChi InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/t10-,15+/m0/s1
PubChem CID 449069
MDL Number MFCD01714949
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


(−)-Huperzine A is a potent and reversible inhibitor of acetylcholinesterase. It shows an IC₅₀ value of 82 nM against acetylcholinesterase in the rat cortex in vitro. It also acts as an antagonist of the N-methyl-D-aspartate (NMDA) receptor and inhibits NMDA induced toxicity. It is beneficial in improving cognitive function in Alzheimer’s disease.

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