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Product Details
| Alternate Name | Selagine, (1R,9R)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one; 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)- |
|---|---|
| Appearance | White crystalline powder |
| CAS # | 102518-79-6 |
| Molecular Formula | C₁₅H₁₈N₂O |
| Molecular Weight | 242.32 |
| Purity | ≥ 98% |
| Solubility | ~20 mg/ml in DMSO |
| SMILES | CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3 |
| InChi | InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/t10-,15+/m0/s1 |
| InChi Key | ZRJBHWIHUMBLCN-ZUZCIYMTSA-N |
| PubChem CID | 449069 |
| MDL Number | MFCD01714949 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
(−)-Huperzine A is a potent and reversible inhibitor of acetylcholinesterase. It shows an IC₅₀ value of 82 nM against acetylcholinesterase in the rat cortex in vitro. It also acts as an antagonist of the N-methyl-D-aspartate (NMDA) receptor and inhibits NMDA induced toxicity. It is beneficial in improving cognitive function in Alzheimer’s disease.
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