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Human Tau-383

A tau isoform
Catalog #: P1621
SKU-Size Size Price Qty
P1621-20 20 μg
$245.00
P1621-50 50 μg
$495.00
More Sizes Get Quote

Product Details

Alternate Name Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; mAP; MAPTL; MTBT1; Tau 0N4R; tau isoform 3; ht24; 4RS tau; Isoform Tau-D
Accession # P10636; NP_058518
Source E.coli
Appearance Liquid
Molecular Weight 42.1 kDa
Purity by SDS-PAGE ≥ 85%
Amino Acid Sequence The target protein is expressed with the sequence (aa 1-383) of human tau-383 fused to His-tag at the N-terminus.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tau is a neuronal microtubule-associated protein. It stabilizes microtubules in axons. Tau protein become hyperphosphorylated and forms insoluble aggregates called neurofibrillary tangles in Alzheimer's disease. The accumulation of abnormal tau aggregates causes cytoxicity, which is described as a gain-of-toxic function model. Tau gene undergoes alternative splicing, giving rise to six different isoforms. Tau-383 isoform contains exon 10 and lacks exons 2 and 3.


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