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Human β-Secretase (BACE1) Inhibitor Screening Kit (Fluorometric)

Highly Sensitive Assay for screening potential BACE1 inhibitors
Catalog #: K720
$575.00

Product Details

Cat # +Size K720-100
Size 100 assays
Kit Summary • Detection method- Fluorescence (Ex/Em: 335-355/ 495-510 nm)
• Species reactivity-
• Applications- Convenient fluorescence method for screening potential BACE1 inhibitors.
Detection Method Fluorescence (Ex/Em= 345/500 nm)
Applications Screening/characterizing/studying potential inhibitors of Human β-Secretase (BACE1)
Features & Benefits • Simple procedure; takes ~ 1 hour
• Fast and convenient
• The assay is sensitive, stable and high-throughput adaptable.
Kit Components • BACE1 Assay Buffer
• BACE1 Substrate (in DMSO)
• BACE1
• BACE1 Inhibitor Control (in DMSO)
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not For Use in Humans.

Details

β-Secretase (Beta-site amyloid precursor protein (APP) cleaving enzyme 1/BACE1), participates in the initial cleavage of amyloid precursor-APP generating two soluble N-terminal and C-terminal fragments. Another secretase isozyme, γ-Secretase, cleaves C-terminal fragment producing amyloid β. Accumulation of amyloid β in brain results in the formation of amyloid plaques, which contribute in the development of Alzheimer’s disease (AD) in humans. Therefore, screening for novel and specific inhibitors of human β-Secretase (BACE1) has become critical in Alzheimer’s Disease-related drug discovery research. In BioVision’s Human β-Secretase (BACE1) Inhibitor Screening Kit, human BACE1 cleaves a quenched substrate, specific for BACE1, generating a product with high fluorescence that can be measured at Ex/Em= 435/500 nm. In the presence of BACE1 Inhibitor (control included in this kit), the enzymatic cleavage is impeded and could be used to screen for new inhibitor compounds. The assay is high-throughput adaptable and can be completed in less than 1 hr


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