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Human recombinant UBE2R1 (CDC34)

Ubiquitin conjugating enzyme involved in conjugation of ubiquitin to target substrates.
Catalog #: 6436
$290.00

Product Details

Cat # +Size 6436-3
Size 3 nmol
Alternate Name Human recombinant UBE2R1 (CDC34), CDC-34, Ubiquitin-conjugating enzyme E2 R1, Ubiquitin-protein ligase R1, Ubiquitin-conjugating enzyme E2-32 kDa complementing, E2-CDC34, CDC34, EC 6.3.2.19, UBC3.
Gene Symbol CDC34
Gene ID 997
Accession # P49427
Appearance Liquid
Physical Form Description 75 µL of a 40 µM solution (3 nmoles) in 50 mM Tris, pH 7.5, 150 mM NaCl, 10 mM DTT and 10% glycerol.
Molecular Weight 27.730 kDa with His Tag.
Purity by SDS-PAGE ≥95%
Biological Activity Protein concentration of 100 nM - 1 µM is recommended for in vitro conjugation.
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

UBE2R1 is important in the control of cell cycle and DNA replication. In association with different E3 complexes, including SCF, it has been shown to target many different substrates for ubiquitination and degradation during cell division, signal transduction, and development. UBE2R1 substrates include B-Myb, Wee1, MyoD, ATF5, p27Xic1, and p27Kip1. Additionally, substrates such as p21Cip1, E2F, cyclin E, and cyclin D are putative substrates of UBE2R1 by virtue of their SCF requirement for proteolysis. This protein is useful for in vitro ubiquitinylation reactions.


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