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Human recombinant UBE2D3

Ubiquitin conjugating enzyme involved in conjugation of ubiquitin to target substrates.
Catalog #: 6430
$290.00

Product Details

Cat # +Size 6430-3
Size 3 nmol
Alternate Name Ubiquitin-conjugating enzyme E2 D3, Ubiquitin-protein ligase D3, Ubiquitin carrier protein D3, Ubiquitin-conjugating enzyme E2-17 kDa 3, UBC4/5, UBCH5C, MGC5416, MGC43926, UBE2D3.
Gene Symbol UBE2D3
Gene ID 7323
Accession # P61077
Appearance Liquid
Physical Form Description 75 µL of a 40 µM solution (3 nmoles) in 25 mM Tris, pH 7.5, 150 mM NaCl, 10 mM DTT and 10% glycerol.
Molecular Weight 28.707 kDa with a His6SUMO Tag
Purity by SDS-PAGE ≥95%
Biological Activity Typical enzyme concentration of 100 nM - 1 mM is used for in vitro conjugation, depending on conditions.
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

UBE2D3 (UbcH5b) is an E2 (ubiquitin conjugating enzyme) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E3 enzymes. The UbcH5 family (including UbcH5a and UbcH5c, having 88% and 89% sequence identity with UbcH5b respectively) are the human homologues of the Saccharomyces cerevisiae UBC4/5 family (~79% sequence identity). Members of the UbcH5 family have been implicated in a number of inflammatory and cancer pathways including the ubiquitylation of p53 and IκBα with the help of different E3 ligases (Hdm2 and SCF complexes respectively).


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