Product Details
| abID | ab168041 |
|---|---|
| Cat # +Size | 6369-50 |
| Size | 50 μg |
| Alternate Name | Protein phosphatase 1G, PP2CG, PPP2CG, MGC1675, MGC2870, PP2CGAMMA. |
| Gene Symbol | PPM1G |
| Gene ID | 5496 |
| Accession # | O15355 |
| Source | E. Coli |
| Appearance | Liquid |
| Physical Form Description | 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1 mM DTT, 0.1 M NaCl, and 0.1 mM PMSF. |
| Molecular Weight | 61.4 kDa (566 aa, 1-546 aa + NT His-Tag) |
| Purity by SDS-PAGE | ≥85% |
| Biological Activity | Specific activity: >5,000 units/mg. |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGGGTGEE PGSQGLNGEA GPEDSTRETP SQENGPTAKA YT |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
PPM1G is part of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1G is accountable for the dephosphorylation of Pre-mRNA splicing factors, an important factor for the formation of functional spliceosome. PPM1G regulates cell cycle progression. PPM1G mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes. The degradation of p21/WAF1 induced by PPM1G is mediated in a proteasome-dependent manner. Protein phosphatase 1G regulates assembly and function of the beta-catenin degradation complex.
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