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Human Recombinant PP2C alpha

Negative regulator of cell stress response pathways
Catalog #: 6303
$280.00

Product Details

Cat # +Size 6303-100
Size 100 μg
Alternate Name Protein phosphatase 1A (formerly 2C), human recombinant PP2C alpha, hrPP2C alpha, human PP2C alpha, recombinant PP2C alpha, magnesium-dependent, alpha isoform, PPM1A, PP2CA, PP2C-ALPHA.
Gene Symbol PPM1A
Gene ID 5494
Accession # P35813
Source E. coli
Appearance Liquid
Physical Form Description 1 mg/ml solution in 10 mM Tris-HCl, pH 7.5, 50 mM NaCl, 2 mM DTT, 1 mM MnCl2, 20% glycerol.
Molecular Weight 46.6 kDa (418aa)
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per 1 μg of protein (determined by LAL method)
Biological Activity >8,000 units/mg.
Amino Acid Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWIL FFAVYDGHAG SQVAKYCCEH LLDHITNNQD FKGSAGAPSV ENVKNGIRTG FLEIDEHMRV MSEKKHGADR SGSTAVGVLI SPQHTYFINC MGAF LDKPKMEKHN AQGQGNGLRY GLSSMQGWRV EMEDAHTAVI GLPSGLESWS GDSRGLLCRN RKVHFFTQDH KPSNPLEKER IQNAGGSVMI QRVNGSLAVS R
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Protein phosphatase 2C (PP2C alpha) is a Mn2+- or Mg2+- dependent protein serine/threonine phosphatase that is essential for regulating cellular stress response in eukaryotes. The protein coding region of PP2C alpha (amino acids 1-382) was cloned into an E. coli expression vector. PP2C alpha was overexpressed in E. coli as a soluble His-tag fusion protein, and it was purified by conventional column chromatographic techniques.


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