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Human Recombinant PKLR

Catalyzes the rate-limiting step of glycolysis
Catalog #: 6373
$355.00

Product Details

Cat # +Size 6373-50
Size 50 μg
Alternate Name Pyruvate kinase isozyme R/L, PK1, PKL, PKR, PKRL, RPK.
Gene Symbol PKLR
Gene ID 5313
Accession # P30613
Source E. Coli
Appearance Liquid
Physical Form Description 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 1 mM DTT and 10% glycerol.
Molecular Weight 59.2 kDa (549 aa, 47-574 aa + NT His-Tag)
Purity by SDS-PAGE ≥90%
Biological Activity Specific activity: >0.1 unit/mg.
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MLTQELGTAF FQQQQLPAAM ADTFLEHLCL LDIDSEPVAA RSTSIIATIG PASRSVERLK EMIKAGMNIA RLNFSHGSHE YHAESIANVR EAVESFAGSP LSYRPVAIAL DTKGPEIRTG ILQGGPESEV ELVKGSQVLV TVDPAFRTRG NANTVWVDYP NIVRVVPVGG RIYIDDGLIS LVVQKIGPEG LVTQVENGGV LGSRKGVNLP GA
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

PKLR is a pyruvate kinase which catalyzes the trans phosphorylation of Phosphoenolpyruvate into pyruvate and ATP. That is the rate-limiting step of glycolysis. PKLR gene encodes the L- and R-type isoenzymes through alternate splicing events controlled by different promoters. The L-type isoform can also appear as a tetramer and is upregulated by glucose with implications in maturity-onset diabetes of the young.


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