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Human Recombinant Cyclophilin A

An immunophilin family protein catalyzing the isomerization of peptide bonds
Catalog #: 6311
$325.00

Product Details

Cat # +Size 6311-100
Size 100 μg
Alternate Name Peptidylprolyl isomerase A, PPIA, CYPA, CYPH
Gene Symbol PPIA
Gene ID 5478
Accession # P62937
Source E. coli
Appearance Liquid
Physical Form Description 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20 mM NaCl, 0.5 mM DTT, 10% glycerol.
Molecular Weight 20 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per 1 μg of protein (determined by LAL method)
Biological Activity Specific activity is > 270 nmoles/min/mg
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLE
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Cyclophilin A is a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. It has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, Cyclophilin A is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.


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