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Human Recombinant Carbonic anhydrase 2

Preserves acid-base balance in blood and other tissues
Catalog #: 6390
$355.00

Product Details

Cat # +Size 6390-100
Size 100 μg
Alternate Name CA-II, CAC, Carbonic anhydrase 2, Carbonate dehydratase 2, can, cynT2, yadF, b0126, JW0122, Carbonic Anhydrase II.
Gene Symbol CA2
Gene ID 760
Accession # P00918
Source E. Coli
Appearance Liquid
Physical Form Description 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 50 mM NaCl, 1 mM DTT and 10% glycerol.
Molecular Weight 29.2 kDa (260 aa, 1-260 aa)
Purity by SDS-PAGE ≥95%
Biological Activity Specific activity is 50-70 nmoles/min/µg and was obtained by measuring the increase in the amount of p-nitrophenol by its esterase activity.
Amino Acid Sequence MSHHWGYGKH NGPEHWHKDF PIAKGERQSP VDIDTHTAKY DPSLKPLSVS YDQATSLRIL NNGHAFNVEF DDSQDKAVLK GGPLDGTYRL IQFHFHWGSL DGQGSEHTVD KKKYAAELHL VHWNTKYGDF GKAVQQPDGL AVLGIFLKVG SAKPGLQKVV DVLDSIKTKG KSADFTNFDP RGLLPESLDY WTYPGSLTTP PLLECVTWIV LKEPISVSSE QVLKFRKLNF NG
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

The enzyme Carbonic anhydrase 2 (CA2) is a part of the enzyme family that catalyses rapid inter-conversion of carbon dioxide & water to bicarbonate, carbonic acid and protons (CO2 + H2O to HCO3 + H), a reaction that occurs rather slowly in the absence of a catalyst. The majority of carbonic anhydrases enclose a zinc ion in their active site and therefore is classified as metalloenzymes. The most important function of Carbonic anhydrase is known to preserve acid-base balance in blood and other tissues, and to help transport carbon dioxide of tissues. Carbonic anhydrases have been found in all kingdoms of life. Mammalian carbonic anhydrase is monomeric and belongs to the alpha class. Mutations in the CA2 gene result in the CA2 deficiency syndrome, an autosomal recessive disorder that produces osteoporosis, renal tubular acidosis and cerebral calcification.


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