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Human Livin/BIRC7

An apoptosis inhibitor protein
Catalog #: P1600
SKU-Size Size Price Qty
P1600-10 10 μg
$95.00
P1600-50 50 μg
$380.00
More Sizes Get Quote

Product Details

Alternate Name KIAP, LIVIN, ML-IAP, RNF50, MLIAP
Accession # AAH14475.1
Source E.Coli
Physical Form Description Liquid
Molecular Weight The recombinant human Livin/BIRC7 consists of 304 amino acids with a predicted molecular mass of 33.6 kDa. It migrates as an approximately 35 kDa band in SDS-PAGE under reducing conditions.
Purity by SDS-PAGE >85% as determined by SDS-PAGE
Biological Activity Human Livin/BIRC7 reversibly inhibits DEVD-AFC cleavage activity in cell extracts activated by the addition of cytochrome c and dATP. The IC₅₀ for this effect is typically 0.6-3.0 μM.
Amino Acid Sequence A DNA sequence encoding the human Livin/BIRC7 (AAH14475.1) (Met1-Ser298) is expressed with a polyhistide tag at the C-terminus. Handling: Centrifuge the vial prior to opening.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Livin/BIRC7 is a member of the inhibitor of apoptosis protein (IAP) family. Its inhibits apoptosis through the inhibition of CASP3, CASP7, CASP9 and shows E3 ubiquitin-protein ligase activity. It promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. It is expressed in fetal tissues and most solid tumors in humans. Livin/BIRC7 expression is a novel prognostic marker in adult acute leukemia. It might be involved in adrenocortical tumorigenesis and represents a new molecular marker of malignancy.


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