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Human Lactate Dehydrogenase A Inhibitor Screening Kit (Colorimetric)

Industry's first kit to screen/study/characterize potential inhibitors of LDH
Catalog #: K492
$445.00

Product Details

Cat # +Size K492-100
Size 100 assays
Kit Summary • Detection method - Absorbance (OD = 450 nm).
• Applications-Screening/characterizing/studying potential inhibitors of Lactate Dehydrogenase A
Detection Method Absorbance (OD = 450 nm).
Applications Screening/characterizing/studying potential inhibitors of Lactate Dehydrogenase A
Features & Benefits • Simple and sensitive assay.
• Fast protocol - can be performed in 30 min.
• HTP adaptable.
Kit Components • LDHA Assay Buffer
• LDHA Substrate Mix
• LDHA
• LDHA Inhibitor Control
• LDHA Dilution Buffer
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The human oxidoreductase Lactate Dehydrogenase A (LDHA) (EC:1.1.1.27) is a key enzyme in lactic acid metabolism. It interconverts pyruvate and NADH to lactate and NAD+ respectively. In mammals, LDHA exists as a tetramer and is primarily found in skeletal muscle tissues. LDHA is a common marker to assay for tissue damage and is also known to promote tumor proliferation in breast, lung, and pancreatic cancer patients. In BioVision’s LDHA Inhibitor Screening Kit, LDHA catalyzes the conversion of lactate to an intermediate that interacts with a probe to develop a color that can be measured at OD 450 nm. In the presence of a LDHA specific inhibitor, the reaction is impeded. A LDHA Inhibitor Control is included to compare the efficacy of the sample inhibitors. The assay is high-throughput adaptable and can be completed in less than 1 hr


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