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Human Inosine-5’-Monophosphate Dehydrogenase (IMPDH) Inhibitor Screening Assay Kit

High-throughput compatible, quick and easy screening for Neprilysin inhibitors; Includes human Neprilysin.
Catalog #: K495

In stock


Product Details

Cat # +Size K495-100
Size 100 assays
Kit Summary • Detection method- Colorimetric (OD 450 nm)
• Application-Screening/characterizing/studying IMPDH inhibitors/activators
Detection Method Colorimetric (OD 450 nm)
Species Reactivity Human
Applications Screening/characterizing/studying IMPDH inhibitors/activators
Features & Benefits • Simple and reliable test to screen IMPDH inhibitors/activators
• High-throughput compatible
• Includes Inhibitor Control (MPA)
Kit Components • Assay Buffer
• IMPDH Substrate
• IMPDH Detection
• IMPDH2 Enzyme
• MPA (10 mM)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Inosine monophosphate dehydrogenase, IMPDH, (E.C. is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis and it is essential for lymphocyte proliferation. IMPDH oxidizes inosine 5’-monophosphate (IMP) to xanthine 5’-monophosphate (XMP) using NAD as a cofactor. It plays a critical role in cell growth and in the malignancy of some tumors such as pancreatic, colon and bladder cancers. IMPDH2 is the predominant isoform of IMPDH and is specifically linked to a wide range of cancers and lymphocyte proliferation. IMPDH is recognized as a validated target as antiviral, antiparasitic, antimicrobial, antileukemic and immunosuppressive agents. In BioVison’s IMPDH inhibitor screening assay, IMP is oxidized by IMPDH producing a series of intermediates, which react with the probe to generate a colorimetric signal (OD 450 nm). The signal is directly proportional to the IMPDH activity and has a very low background. In the presence of a IMPDH inhibitor such as mycophenolic acid (MPA), the reaction is arrested, thus decreasing the signal. BioVision’s IMPDH assay is fast, sensitive and reproducible and is suitable for functional assays, high-throughput screening and preclinical studies in drug discovery.

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