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Human Hec1

A component of the kinetochore outer layer
Catalog #: P1671
$345.00

Product Details

Cat # +Size P1671-50
Size 50 μg
Alternate Name Kinetochore protein NDC80 homolog; Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC
Accession # O14777
Source E.coli
Appearance Lyophilized protein
Molecular Weight 41.01 kDa
Purity by SDS-PAGE ≥ 90%
Reconstitution Instructions Reconstitute in sterile water to a concentration of 1 mg/ml.
Amino Acid Sequence The target protein is expressed with the sequence Pro290-Glu642 of human Hec1 with a His tag at the N-terminus.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Hec1 is a component of the kinetochore outer layer, which is required for chromosome segregation and spindle checkpoint activity. It is required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. It is overexpressed in a variety of human cancers and maybe used for the prognosis of primary breast cancer.


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