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Human GLS1, Recombinant

A mitochondrial enzyme that hydrolyzes glutamine producing glutamate and ammonia
Catalog #: P1656
SKU-Size Size Price Qty
P1656-10 10 μg
$165.00
P1656-50 50 μg
$575.00
More Sizes Get Quote

Product Details

Alternate Name Glutaminase, cKGA, catalytic domain of KGA, Glutaminase kidney isoform, mitochondrial, KGA, GLS1, GAC, GAM, KGA
Accession # O94925
Source E. coli
Appearance Colorless liquid
Physical Form Description Liquid
Molecular Weight 36.7 kDa
Purity by SDS-PAGE ≥ 95%
Biological Activity Biological activity was performed using BioVision’s Glutaminase Activity Assay Kit (Colorimetric) (Cat# K2067-100).
Amino Acid Sequence aa 221-533
Handling Centrifuge the vial prior to opening.
Storage Conditions -70ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Glutaminase (EC 3.5.1.2) is a mitochondrial enzyme that hydrolyzes glutamine producing glutamate and ammonia. GLS is one of the two key enzymes including glutamine synthetase that are responsible for glutamine homeostasis. Since glutamine is a major metabolic substrate involved in gluconeogenesis, its homeostasis is tightly controlled. Glutaminase has tissue-specific roles in multiple organs, with the isoform GLS1 being expressed in kidneys and brain, and GLS2 being expressed in the liver. It is involved in maintenance of acid-base homeostasis by producing ammonia during renal acidosis in kidneys and regulation of glutamate, which acts as a neurotransmitter in the brain. BioVision’s recombinant GLS1 is catalytic domain of the original GLS1, which shows greater activity and excellent stability.


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