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Human Ghrelin

based on 1 citations in multiple journalsHuman Ghrelin14.1 4
Hunger stimulating hormone
Catalog #: 4990
SKU-Size Size Price Qty
4990-1000 1 mg
$345.00
4990-100 100 μg
$95.00
More Sizes Get Quote

Product Details

Alternate Name Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46Human Ghrelin (Ser3 modified), Ghrelin, h-Ghrelin, rh-Ghrelin, recombinant human Ghrelin, Ghrelin (Ser3 modified), recombinant
Gene Symbol GHRL
Gene ID 51738
Accession # Q9UBU3
Appearance Lyophilized peptide
Physical Form Description Lyophilized peptide
Molecular Weight 3.374 kDa
Reconstitution Instructions Reconstitute in PBS containing at least 0.1% BSA to a concentration of 1.0 mg/ml.
Amino Acid Sequence GS(X)FLSPEHQRVQQRKESKKPPAKLQPR X = serine modified with n-octanoic acid
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Ghrelin (‘ghre’ is the Proto-Indo-European root of the word ‘grow’) has been identified as the endogenous ligand for the GHS-R (growth hormone secretagogues receptor). Ghrelin is expressed in the stomach, small and large intestines, and brain regions that are involved in the regulation of food intake. Both ghrelin and GHS-R expression is also detected in the heart, suggesting that Ghrelin might have some cardiovascular effects. Ghrelin administration stimulates GH secretion but also causes weight gain by increase food intake. Mature human and rat Ghrelin (28 a.a.) are produced from a 117 amino acid precursor. Ghrelin has an unusual modification at Ser3 residue that is n-octanoylated and is essential for biological activity. Ghrelin is the first known example of a bioactive peptide modified by an acyl acid


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Ianotorno M et al. (2007) Am J. Physiol. Endocrinol. Metab. 292: E756-E764.
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