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Human Fibrinogen (PAD2 Citrullinated)

A critical factor in blood clotting, inflammation, and rheumatoid arthritis
Catalog #: P1718
SKU-Size Size Price Qty
P1718-50 50 µg
$145.00
P1718-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Alternate Name Fib2; FGA; HEL-S-78p; FGB; FGG
Gene ID α - 2243; β - 2244; γ - 2266
Accession # α - P02671; β - P02675; γ - P02679
Source Human plasma
Appearance Liquid protein
Molecular Weight α - 2 isoforms at 95 kDa and 69.8 kDa; β - 55.9 kDa; γ - 51.5 kDa
Purity by SDS-PAGE ≥ 95%
Amino Acid Sequence Purified from human plasma that tested negative for HBsAg and for antibodies to HIV and HCV; citrullinated with human recombinant PAD2
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Fibrinogen is a glycoprotein complex composed of three different polypeptides (α, β, γ) that is cleaved by thrombin to form an insoluble fibrin matrix that acts as a plasma clotting factor. Cleavage products of fibrinogen and fibrin regulate cell adhesion and activate chemotaxis. Chronic inflammation can induce protein arginine deiminases (such as PAD2 and PAD4) to citrullinate fibrinogen, which has been associated with auto-antibodies in rheumatoid arthritis.


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