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Human Chorionic Gonadotropin, β Subunit

Unique beta subunit of human chorionic gonadotropin; native protein isolated from human urine
Catalog #: P1714
$295.00

Product Details

Cat # +Size P1714-100
Size 100 µg
Alternate Name Choriogonadotropin subunit beta; chorionic gonadotropin chain beta; CG-Beta; HCGB; CGB; HCG
Gene ID 93659
Accession # P0DN86
Source Human urine
Appearance Lyophilized protein
Physical Form Description Lyophilized powder
Molecular Weight 22 kDa
Purity by SDS-PAGE ≥ 95%
Reconstitution Instructions Reconstitute using neutral pH buffer of choice. Avoid extreme high and low pH.
Amino Acid Sequence Full length native protein (beta subunit only)
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Chorionic gonadotropin (CG) is produced by the trophoblastic cells of the placenta and stimulates the ovaries to release steroids essential for maintaining pregnancy. The four human glycoprotein hormones (CG, luteinizing hormone, follicle stimulating hormone, and thyroid stimulating hormone) are dimers consisting of alpha and beta subunits. The alpha subunits of these hormones are identical, while they each have unique beta subunits that allow the hormones to bind specific receptors on target cells to activate distinct downstream signaling pathways. The beta subunit of CG is encoded by six highly homologous genes which are arranged in tandem and inverted pairs on chromosome 19. Abnormalities in the CG beta subunit can cause ectopic pregnancy.


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