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Product Details
| Cat # +Size | P1714-100 |
|---|---|
| Size | 100 µg |
| Alternate Name | Choriogonadotropin subunit beta; chorionic gonadotropin chain beta; CG-Beta; HCGB; CGB; HCG |
| Gene ID | 93659 |
| Accession # | P0DN86 |
| Source | Human urine |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized powder |
| Molecular Weight | 22 kDa |
| Purity by SDS-PAGE | ≥ 95% |
| Reconstitution Instructions | Reconstitute using neutral pH buffer of choice. Avoid extreme high and low pH. |
| Amino Acid Sequence | Full length native protein (beta subunit only) |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Chorionic gonadotropin (CG) is produced by the trophoblastic cells of the placenta and stimulates the ovaries to release steroids essential for maintaining pregnancy. The four human glycoprotein hormones (CG, luteinizing hormone, follicle stimulating hormone, and thyroid stimulating hormone) are dimers consisting of alpha and beta subunits. The alpha subunits of these hormones are identical, while they each have unique beta subunits that allow the hormones to bind specific receptors on target cells to activate distinct downstream signaling pathways. The beta subunit of CG is encoded by six highly homologous genes which are arranged in tandem and inverted pairs on chromosome 19. Abnormalities in the CG beta subunit can cause ectopic pregnancy.
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