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Human CellExp™LRP-5, Fc tag, Human Recombinant

Frizzled protein family members that plays a key role in skeletal homeostasis
Catalog #: P1457
SKU-Size Size Price Qty
P1457-10 10 µg
$105.00
P1457-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name LRP-5, LRP-5, LRP-7, LRP7, LR3
Gene Symbol LRP5
Gene ID 4041
Accession # O75197-1
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized
Molecular Weight This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 96.6 kDa. The protein migrates as 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity by SDS-PAGE >90%
Endotoxin Level Less than 0.1 EU per μg by the LAL method.
Biological Activity Immobilized Human Dkk-1, His Tag 5 μg/mL (100 μL/well) can bind Human LRP-5, Mouse IgG2a Fc Tag with a linear range of 0.01-0.313 μg/mL
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Amino Acid Sequence Glu 644 - Gln 1263
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.


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