Product Details
| Alternate Name | T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2 |
|---|---|
| Gene Symbol | IL2 |
| Gene ID | 3558 |
| Accession # | P60568 |
| Source | HEK 293 cells |
| Appearance | Lyophilized powder |
| Physical Form Description | Lyophilized |
| Molecular Weight | 16 kDa with a 6×His tag at the C-terminus |
| Purity by SDS-PAGE | > 95% by SDS - PAGE |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex. |
| Amino Acid Sequence | Ala 21 – Thr 153 |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Interleukin-2 (IL-2) is a potent immuno-modulator, which mediates a wide range of immune and inflammatory responses and is important for the proliferation of T and B lymphocytes. IL-2 is one of the key cytokines for the immune system, tolerance and immunity. It has been approved for the treatment of metastatic renal cell carcinoma and metastatic melanoma in cancer immunotherapy with long term disease control. In addition to being used as monotherapy, IL-2 can also be combined with other anticancer immunotherapies, such as adoptive cell transfer, vaccination, and blockade of immune checkpoint inhibitory molecules, such as cytotoxic T lymphocyte-associated antigen 4 and programmed death 1 monoclonal-antibodies as a promising treatment for metastatic cancer.
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