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Human CellExp™ Vitronectin (His Tag, Active), Mouse Recombinant

Promotes cell adhesion and spreading
Catalog #: P1754
SKU-Size Size Price Qty
P1754-50 50 µg
$195.00
P1754-100 100 µg
$295.00
More Sizes Get Quote

Product Details

Alternate Name S-Protein; Serum-spreadking factor; Vn; Vtn; AI256434 protein
Gene ID 22370
Accession # P29788
Source HEK 293 cells
Appearance Lyophilized protein
Physical Form Description Lyophilized powder
Molecular Weight 75 to 85 kDa (observed due to glycosylation)
Purity by SDS-PAGE > 85%
Formulation Lyophilized from sterile PBS, pH 7.4
Endotoxin Level < 1.0 EU per µg as determined by the LAL method.
Biological Activity Measured by the ability of the immobilized protein to support the adhesion of DU145 human prostate carcinoma cells. When cells are added to mouse vitronectin coated plates (10 μg/mL, 100 μL/well), > 60% cells will adhere specifically after 30 minutes at 3
Amino Acid Sequence Met 1 to Lys 478 (predicted N-terminus is Asp 20) with C-terminal polyhistidine tag
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interacts with glycosaminoglycans and proteoglycans, and functions as a regulator of diverse physiological processes such as blood coagulation and cell attachment and spreading. The molecule can be recognized by certain integrin family members and serves as a cell-to-substrate adhesion molecule. Vitronectin also inhibits the membrane-damaging effect of the complement pathway. Due to its many diverse functions, vitronectin is implicated in coronary atherosclerosis, hemostasis, and tumor malignancy.


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