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Human CellExp™ VEGF-D, Human recombinant

Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth
Catalog #: P1133
$315.00

Product Details

Cat # +Size P1133-10
Size 10 μg
Alternate Name FIGF, VEGFD
Gene Symbol VEGFD
Gene ID 2277
Accession # O43915
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.
Molecular Weight 13 kDa
Purity by > 95%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Immobilized Human VEGF R3, Fc Tag at 5μg/mL (100 μl/well) can bind Human VEGF-D, His Tag, Strep Tag with a linear range of 0.08-0.6 μg/ml.
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF), which belongs to the PDGF / VEGF growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. This secreted protein VEGF-D / FIGF undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. The structure and function of this protein is similar to those of VEGFC. FIGF / VEGF-D is highly expressed in lung, heart, small intestine and fetal lung. FIGF / VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR / FLK1) and VEGFR-3 (FLT4) receptors.


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