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Human CellExp™ VEGF-B, human recombinant

Plays a role only in the maintenance of newly formed blood vessels during pathological conditions
Catalog #: 7230
$295.00

Product Details

Cat # +Size 7230-10
Size 10 μg
Alternate Name VRF, VEGFL, VEGFB, VEGF-B
Gene Symbol VEGF-B
Gene ID 7423
Accession # P49765
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Molecular Weight The protein is fused with 6 × His tag at the C-terminus and has a calculated MW of 20.2 kDa. The predicted N-terminus is Arg 22. DTT-reduced Protein migrates as 15-18 kDa and 33-35 kDa due to glycosylation.
Purity by SDS-PAGE ≥95%
Endotoxin Level < 0.1 ng/μg of protein (<1EU/μg).
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Vascular endothelial growth factor B (VEGFB) also known as VEGF-related factor (VRF), is a secreted O-glycosylated protein, which belongs to the PDGF/VEGF growth factor family. VEGFB is expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. VEGFB is growth factor for endothelial cells. VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. VEGF-B also plays an important role on several types of neurons. It is important for the protection of neurons in the retina and the cerebral cortex during stroke and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.


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