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Human CellExp™ TRAIL R2 / TNFRSF10B, Mouse recombinant

Promotes the activation of NF-kappa-B
Catalog #: P1421
$295.00

Product Details

Cat # +Size P1421-50
Size 50 µg
Alternate Name TNFRSF10B, TRAILR2, TRAIL-R2, CD262,DR5, KILLER, TRICK2, ZTNFR9, TRICKB
Gene Symbol Tnfrsf10b
Gene ID 21933
Accession # Q9QZM4-1
Source HEK 293 Cells
Appearance Lyophilized powder
Physical Form Description Lyophilized powder
Molecular Weight This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.1 kDa. The protein migrates as 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity by SDS-PAGE >90%
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Amino Acid Sequence AA Asn 53 - Lys 180
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.


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