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Human CellExp™ TPO, Mouse Recombinant

Stimulates the proliferation and maturation of megakaryocytes
Catalog #: P1565
SKU-Size Size Price Qty
P1565-10 10 μg
$125.00
P1565-50 50 μg
$625.00
More Sizes Get Quote

Product Details

Alternate Name Thpo, C-mpl ligand,ML, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand, Mgdf, Ml, Mpllg, Tpo, thrombopoietin isoform 1
Gene Symbol Thpo
Gene ID 21832
Accession # P40226
Source HEK 293 cells
Appearance Liquid
Physical Form Description Liquid
Molecular Weight 36.4 kDa (His-tag at C-terminus)
Purity by SDS-PAGE >90%
Endotoxin Level < 1 EU per 1ug of protein (determined by LAL method)
Biological Activity Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 range ≤4ng/ml.
Amino Acid Sequence aa 22-356
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Megakaryocytopoiesis is the cellular development process that leads to platelet production. It is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Recombinant mouse Thrombopoietin, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.


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