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Human CellExp™ TGF-beta 3, Human Recombinant

A protein that controls proliferation, cellular differentiation, & other functions in most cells
Catalog #: 6481
SKU-Size Size Price Qty
6481-10 10 µg
$525.00
6481-50 50 µg
$2,315.00
More Sizes Get Quote

Product Details

Alternate Name Transforming Growth Factor-beta3, TGFB3, ARVD, FLJ16571, TGF-beta 3.
Gene Symbol TGFB3
Gene ID 7043
Accession # P10600
Source Human 293 cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized from 50 mM sodium acetate, pH 4.5 and 350 mM NaCl.
Molecular Weight 25 kDa, homodimer, nonglycosylated
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity ED₅₀ is typically 0.1 to 0.5 ng/mL. The specific activity was determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).
Reconstitution Instructions Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Transforming growth factor betas (TGFβ) mediate many cell-cell interactions that occur during embryonic development. Three TGFβs have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. TGF-beta 3 influences pathogenesis and pulmonary development.


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