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Human CellExp™ sRANK Ligand, Human Recombinant

Immune signaling facilitator
Catalog #: P1552
SKU-Size Size Price Qty
P1552-10 10 μg
$125.00
P1552-50 50 μg
$475.00
More Sizes Get Quote

Product Details

Alternate Name TNSF11, CD254, tumor necrosis factor ligand superfamily member 11, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine
Gene Symbol OPGL
Gene ID 8600
Accession # O14788
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight 28 kDa (6xHis tag at the N-terminus)
Purity by SDS-PAGE ≥ 95%
Purity by ≥ 95% SEC
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino Acid Sequence Ala 145 – Asp 317
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Receptor activator of nuclear factor kappa-B ligand (RANK-L), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11) or CD254, is a member of the tumor necrosis factor (TNF) superfamily. Receptor activator of nuclear factor kappa-B ligand (RANK) and its ligand RANKL have been described for their key roles in bone metabolism, the central nervous system and the immune system. Subsequently, it has been shown that the RANKL-RANK system also plays a critical role in other bone pathologies, bone metastasis or hormone-driven breast cancer. RANK-L is a ligand for osteoprotegerin (OPG) and functions as a key factor for osteoclast differentiation and activation. Some studies suggest the expression of RANK-L allows sufficient microenvironmental conditions to influence cancer cell migration.


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