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Human CellExp™ sIL-6 receptor, Human Recombinant

A type I cytokine receptor
Catalog #: P1289

In stock

SKU-Size Size Price Qty
P1289-5 5 µg
$115.00
P1289-20 20 µg
$295.00
More Sizes Get Quote

Product Details

Alternate Name soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126, Membrane glycoprotein 80, gp80, IL-6R 1, Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA
Gene Symbol IL6R
Accession # P08887
Source HEK293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized from 1x PBS pH 7.2.
Molecular Weight 37.6 kDa
Purity by SDS-PAGE ≥ 98%
Endotoxin Level <0.1 EU/μg
Biological Activity The ED50 was determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is ≤ 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in 1x PBS, pH 7.2 to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Rα and gp130. The IL-6Rα chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6Rα. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Rα alone. IL-6Rα is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6Rα which consists of only the extracellular domain of the IL-6Rα chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6Rα is a 37.6 kDa protein consisting of the extracellular domain of the IL-6Rα chain (338 amino acid residues).


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