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Human CellExp™ Siglec-2 / CD22, Mouse Recombinant

Mediates B-cell B-cell interactions and involved in the localization of B-cells in lymphoid tissues
Catalog #: P1330

In stock

SKU-Size Size Price Qty
P1330-10 10 μg
$95.00
P1330-50 50 μg
$345.00
More Sizes Get Quote

Product Details

Alternate Name CD22, SIGLEC2, BL-CAM, Leu-14
Gene Symbol CD22
Gene ID 12483
Accession # P35329-1
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
Molecular Weight 78.3 kDa
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per/μg
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 50 μg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.


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