Product Details
| abID | ab84081 |
|---|---|
| Alternate Name | Delta-like protein 4; Drosophila Delta homolog 4 |
| Gene Symbol | DLL-4 |
| Gene ID | 54567 |
| Accession # | Q9NR61 |
| Source | HEK 293 cells |
| Appearance | Lyophilized powder |
| Physical Form Description | Sterile filtered through a 0.2 micron filter. Lyophilized from 1X PBS, pH 7.5. |
| Molecular Weight | 54.3 kDa |
| Purity by SDS-PAGE | ≥95% |
| Endotoxin Level | < 0.1 ng/μg of protein (<1EU/μg). |
| Biological Activity | The sDLL-4, when immobilized at concentrations > 1.5 μg/mL will inhibit myogenesis in C2C12 cells. |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carri |
| Amino Acid Sequence | SGVFQLQLQE FINERGVLAS GRPCEPGCRT FFRVCLKHFQ AVVSPGPCTF GTVSTPVLGT NSFAVRDDSS GGGRNPLQLP FNFTWPGTFS LIIEAWHAPG DDLRPEALPP DALISKIAIQ GSLAVGQNWL LDEQTSTLTR LRYSYRVICS DNYYGDNCSR LCKKRNDHFG HYVCQPDGNL SCLPGWTGEY CQQPICLSGC HEQNGYCSKP AECLCRPGWQ GRLCNECIPH NG |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors. Recombinant human sDLL4 is a 54.3 kDa glycoprotein containing 498 amino-acid residues.
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