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Human CellExp™ SCARB2 /CD36L2 /LIMP2, human recombinant

≥95% pure, active, human cell expressed, human recombinant SCARB2 /CD36L2 /LIMP2 - a lysosomal receptor for glucosylceramidase (GBA) targeting
Catalog #: 7509
SKU-Size Size Price Qty
7509-10 10 μg
$180.00
7509-50 50 μg
$615.00
More Sizes Get Quote

Product Details

Alternate Name SCARB2, CD36L2, LIMP2, LIMPII, LGP85, CD36, AMRF, EPM4, HLGP85, SR-BII
Gene Symbol SCARB2
Gene ID 950 
Accession # Q14108
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM glycine, pH 7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Weight This protein fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 72.5 kDa. The predicted N-terminus is Arg 27. DTT-reduced Protein migrates as 90-115 kDa due to glycosylation.
Purity by SDS-PAGE ≥95%
Endotoxin Level <1 EU/μg by LAL method
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized rh SCARB2 / CD36L2/ LIMP2 Fc Chimera at 5 µg/ml (100 µl/well) can bind rhTSP-2/His with a linear range of 0.1 - 5 µg/ml.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Scavenger receptor class B member 2 (SCARB2) is also known as Lysosome membrane protein 2 (LIMP2), 85 kDa lysosomal membrane sialoglycoprotein (LGP85), CD36 antigen-like 2 (CD36L2, LIMP2), which belongs to the CD36 family. SCARB2 acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. It may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. LIMPII is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Expression of human LIMP2 enables normally unsusceptible cell lines to support the viruses’ propagation and develop cytopathic effects. In addition, LIMP2 also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation. Deficiency of the protein in mice impairs cell membrane transport processes and causes pelvic junction obstruction, deafness, and peripheral neuropathy.


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