Human CellExp™ SARS-CoV-2 Spike RBD (N501Y), Recombinant

Spike RBD (N501Y) mutant increases binding affinity to ACE2
Catalog #: P1644 | abID:

Product Details

Alternate Name COVID-19 Spike RBD protein (N501Y); 2019-nCoV Spike RBD protein (N501Y); SARS-CoV-2 Mutant (N501Y); SARS-CoV-2 (N501Y) mutant protein
Accession # QHD43416.1
Source Human cells
Appearance Liquid
Molecular Weight The predicted molecular weight is 26 kDa. The protein migrates as a 33-36 kDa band under reducing conditions
Purity by SDS-PAGE ≥ 95%
Amino Acid Sequence The target protein is expressed with the sequence Arg319-Ser541(N501Y) of SARS-CoV-2 Spike RBD protein fused with a 6xHis tag at the C-terminus.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not For Use in Humans.


SARS-CoV-2 Spike protein is a large type I transmembrane protein composed of S1 subunit and S2 subunit. During viral infection, the receptor-binding domain (RBD) of the S1 subunit is responsible for the recognition and binding of host receptor ACE2, while the S2 subunit mediates viral cell membrane fusion. The SARS-CoV-2-S1-RBD/ACE2 interaction mediates viral entry into the target cells. The N501Y mutation in the receptor-binding domain (RBD) of SARS-CoV-2 variants increases binding affinity to ACE2.

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