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Human CellExp™ SARS-CoV-2 Spike RBD (L452R, T478K), Recombinant

Recombinant Spike RBD mutant of the SARS-CoV-2 Delta variant
Catalog #: P1744
$625.00

Product Details

Cat # +Size P1744-100
Size 100 µg
Alternate Name COVID-19 Spike RBD protein; 2019-nCoV Spike RBD protein; SARS-CoV-2 Mutant (L452R, T478K)
Gene ID 43740568
Accession # P0DTC2
Source HEK 293 cells
Physical Form Description Lyophilized powder
Molecular Weight 26.6 kDa (calculated); 33-35 kDa (observed due to glycosylation)
Purity by SDS-PAGE ≥ 90%
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally trehalose is added as protectant before lyophilization.
Endotoxin Level < 1 EU per 1 µg of protein as determined by LAL method
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SARS-CoV-2 Spike protein is a large type I transmembrane protein composed of S1 subunit and S2 subunit. During viral infection, the receptor-binding domain (RBD) of the S1 subunit is responsible for the recognition and binding of host receptor ACE2, while the S2 subunit mediates viral cell membrane fusion. The SARS-CoV-2-S1-RBD/ACE2 interaction mediates viral entry into the target cells. The mutations at L452R and T478K were identified in the SARS-CoV-2 Delta (particularly B.1.617.2) variants that originated in India.


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