Human CellExp™ SARS-CoV-2 Spike RBD (E484K)

Spike RBD variant with E84k mutation which mildly increase receptor binding
Catalog #: P1649 | abID:

Product Details

Cat # +Size P1649-50
Size 50 μg
Alternate Name COVID-19 Spike RBD protein (E484K); 2019-nCoV Spike RBD protein (E484K); SARS-CoV-2 Mutant (E484K); SARS-CoV-2 (E484K) mutant protein
Accession # YP_009724390.1
Source Hek293
Appearance Lyophilized protein
Molecular Weight 35 kDa
Purity by SDS-PAGE ≥ 90%
Reconstitution Instructions Reconstitute in sterile water to a concentration of 1 mg/ml.
Amino Acid Sequence The target protein SARS-CoV-2 S Protein RBD (E484K) is expressed with His tag at the C-terminus.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SARS-CoV-2 Spike protein is a large type I transmembrane protein composed of S1 subunit and S2 subunit. During viral infection, the receptor-binding domain (RBD) of the S1 subunit is responsible for the recognition and binding of host receptor ACE2, while the S2 subunit mediates viral cell membrane fusion. The SARS-CoV-2-S1-RBD/ACE2 interaction mediates viral entry into the target cells. The E484K mutant mildly increase receptor binding.

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