Product Details
| Cat # +Size | P1649-50 |
|---|---|
| Size | 50 μg |
| Alternate Name | COVID-19 Spike RBD protein (E484K); 2019-nCoV Spike RBD protein (E484K); SARS-CoV-2 Mutant (E484K); SARS-CoV-2 (E484K) mutant protein |
| Accession # | YP_009724390.1 |
| Source | Hek293 |
| Appearance | Lyophilized protein |
| Molecular Weight | 35 kDa |
| Purity by SDS-PAGE | ≥ 90% |
| Reconstitution Instructions | Reconstitute in sterile water to a concentration of 1 mg/ml. |
| Amino Acid Sequence | The target protein SARS-CoV-2 S Protein RBD (E484K) is expressed with His tag at the C-terminus. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
SARS-CoV-2 Spike protein is a large type I transmembrane protein composed of S1 subunit and S2 subunit. During viral infection, the receptor-binding domain (RBD) of the S1 subunit is responsible for the recognition and binding of host receptor ACE2, while the S2 subunit mediates viral cell membrane fusion. The SARS-CoV-2-S1-RBD/ACE2 interaction mediates viral entry into the target cells. The E484K mutant mildly increase receptor binding.
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