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Product Details
| Alternate Name | S1 protein, Spike glycoprotein Subunit1, S glycoprotein Subunit1, Spike protein S1, novel coronavirus s1 Protein |
|---|---|
| Gene Symbol | S |
| Gene ID | 43740568 |
| Accession # | YP_009724390.1 |
| Source | HEK 293 cells |
| Appearance | Lyophilized powder |
| Physical Form Description | Lyophilized |
| Molecular Weight | 103 kDa (Fc, 6×His tag at the C-terminus) |
| Purity by SDS-PAGE | >90% |
| Endotoxin Level | < 0.1 EU/μg of the protein by LAL method |
| Biological Activity | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human ACE2 at 2μg/mL (100 μL/well) can bind Recombinant SARS-COV-2 Spike S1, the EC50 of SARS-COV-2 Spike S1 is 6.79 ng/mL.|Immobilized Human ACE2 on COOH Chip, can bind SARS-C |
| Reconstitution Instructions | Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. |
| Amino Acid Sequence | Val 11-Arg 682 |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
SARS-CoV is an enveloped, single, and positive-stranded RNA virus. Cell entry of severe acute respiratory syndrome coronavirus (SARS-CoV) is mediated by the viral spike (S) protein. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. For viral entry, the surface unit (S1) of SARS S binds to the cellular receptor angiotensin-converting enzyme 2 (ACE2) and the transmembrane unit (S2) then fuses the viral membrane with a host cell membrane. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. Because the S protein of SARS-CoV is involved in receptor recognition, as well as virus attachment and entry, it represents one of the most important targets for the development of SARS vaccines and therapeutics.
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