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Human CellExp™ SARS-CoV-2 Spike Protein (RBD; 331-524), Recombinant

Glycoprotein that enables viral entry into the host cell
Catalog #: P1544
SKU-Size Size Price Qty
P1544-10 10 μg
$105.00
P1544-50 50 μg
$425.00
More Sizes Get Quote

Product Details

Alternate Name Novel Coronavirus RBD Protein, 2019-nCoV Spike Protein RBD, SARS-CoV-2 S1 RBD Protein
Gene Symbol S
Gene ID 43740568
Accession # HEK 293 cells
Source HEK 293 cells
Appearance Lyophilized protein
Physical Form Description Lyophilized
Molecular Weight ~25 kDa (6×His tag at the C-terminus)
Purity by >95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino Acid Sequence aa 331-524
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The spike (S) glycoprotein of coronaviruses mediates entry into receptor-expressing host cells and plays the most important role in viral attachment, fusion, and entry; therefore, it serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives membrane fusion and eventual entry of the virus. Within the S1 protein, the highly conserved receptor-binding domain (RBD) expresses a high affinity for the Angiotensin converting enzyme 2 receptor (ACE2). Experiments have shown that the RBD fragment blocked S-protein mediated infections and suggests potential as a viral attachment or entry inhibitor against SARS-CoV-2.


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