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Human CellExp™ SARS-CoV-2 S1, Recombinant

A key protein in allowing viral entry into host cells
Catalog #: P1666
SKU-Size Size Price Qty
P1666-10 10 µg
$195.00
P1666-50 50 µg
$375.00
More Sizes Get Quote

Product Details

Alternate Name S1 Protein, Spike glycoprotein subunit1, S glycoprotein subunit1, SARS-CoV-2 S1 Protein
Gene ID 43740568
Accession # P0DTC2
Source HEK 293 cells
Appearance Lyophilized protein
Physical Form Description Lyophilized powder
Molecular Weight ~120 kDa (8xHis tag at the C-terminus)
Purity by SDS-PAGE > 95%
Formulation Lyophilized from 0.22 µm filtered PBS (pH 7.4) with 5% trehalose.
Amino Acid Sequence Val 16 - Arg 685
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The spike (S) glycoprotein of coronaviruses mediates entry into receptor-expressing host cells and plays the most important role in viral attachment, fusion, and entry; therefore, it serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives membrane fusion and eventual entry of the virus. Within the S1 protein, the highly conserved receptor-binding domain (RBD) expresses a high affinity for the Angiotensin converting enzyme 2 (ACE2) receptor and serves as the key binding factor for infection upon human respiratory epithelial cells.


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