Product Details
| Alternate Name | S1 Protein, Spike glycoprotein subunit1, S glycoprotein subunit1, SARS-CoV-2 S1 Protein |
|---|---|
| Gene ID | 43740568 |
| Accession # | P0DTC2 |
| Source | HEK 293 cells |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized powder |
| Molecular Weight | ~120 kDa (8xHis tag at the C-terminus) |
| Purity by SDS-PAGE | > 95% |
| Formulation | Lyophilized from 0.22 µm filtered PBS (pH 7.4) with 5% trehalose |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
SARS-CoV-2, the causative virus of COVID-19, uses the viral Spike (S) protein for host cell attachment and entry. The virus uses multiple host targets including the human protease Furin, Angiotensin converting enzyme 2 (ACE2), Neuropilin-1 (NRP1) and the transmembrane protease serine 2 (TMPRSS2) for host cell entry. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives the membrane fusion and eventual entry of the virus. The S glycoprotein serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. Within the S1 protein, the conserved receptor-binding domain (RBD) binds with a high affinity for ACE2. Recently, fast-spreading variants were identified in UK, South Africa, and Brazil. In November 2020, the CAL.20C or B.1.429 strain was identified throughout California, which contained the L452R mutation, a substitution from a leucine (L) to arginine (R) in the RBD. Due to this change, the California strain is reported to be roughly 20% more contagious. Additionally, the CDC reports a significant impact on neutralization by some, but not all, therapeutics and a moderate reduction in neutralization using convalescent and post-vaccination sera.
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