Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Human CellExp™ SARS-CoV-2 S1 Protein (L452R), Recombinant

A key protein in allowing viral entry into host cells
Catalog #: P1662
SKU-Size Size Price Qty
P1662-10 10 µg
$225.00
P1662-50 50 µg
$425.00
More Sizes Get Quote

Product Details

Alternate Name S1 Protein, Spike glycoprotein subunit1, S glycoprotein subunit1, SARS-CoV-2 S1 Protein
Gene ID 43740568
Accession # P0DTC2
Source HEK 293 cells
Appearance Lyophilized protein
Physical Form Description Lyophilized powder
Molecular Weight ~120 kDa (8xHis tag at the C-terminus)
Purity by SDS-PAGE > 95%
Formulation Lyophilized from 0.22 µm filtered PBS (pH 7.4) with 5% trehalose
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SARS-CoV-2, the causative virus of COVID-19, uses the viral Spike (S) protein for host cell attachment and entry. The virus uses multiple host targets including the human protease Furin, Angiotensin converting enzyme 2 (ACE2), Neuropilin-1 (NRP1) and the transmembrane protease serine 2 (TMPRSS2) for host cell entry. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives the membrane fusion and eventual entry of the virus. The S glycoprotein serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. Within the S1 protein, the conserved receptor-binding domain (RBD) binds with a high affinity for ACE2. Recently, fast-spreading variants were identified in UK, South Africa, and Brazil. In November 2020, the CAL.20C or B.1.429 strain was identified throughout California, which contained the L452R mutation, a substitution from a leucine (L) to arginine (R) in the RBD. Due to this change, the California strain is reported to be roughly 20% more contagious. Additionally, the CDC reports a significant impact on neutralization by some, but not all, therapeutics and a moderate reduction in neutralization using convalescent and post-vaccination sera.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.