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Product Details
| Alternate Name | S1 Protein (D614G); Human CellExp™ SARS-CoV-2 S1 (D614G); Human CellExp™ SARS-CoV-2 S1 (D614G), Recombinant; SARS-CoV-2 S1 (D614G); SARS-CoV-2 S1 Protein (D614G); SARS-CoV-2 S1 Protein (D614G), Recombinant; S1 (D614G); Human CellExp™ SARS-CoV-2 S1 Protein (D614G); Human CellExp™ SARS-CoV-2 S1 (D614G) |
|---|---|
| Source | HEK 293 cells |
| Appearance | Lyophilized powder |
| Molecular Weight | 120 kDa |
| Purity by SDS-PAGE | > 95% |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex. |
| Amino Acid Sequence | Val 16 - Arg 685 |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
SARS-CoV-2, the causative virus of COVID-19, uses the viral Spike (S) protein for host cell attachment and entry. The virus uses multiple factors including the human protease Furin, Angiotensin converting enzyme 2 (ACE2), Neuropilin-1 (NRP1) and the transmembrane protease serine 2 (TMPRSS2) for receptor interactions. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives the membrane fusion and eventual entry of the virus. The S glycoprotein serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. Within the S1 protein, the conserved receptor-binding domain (RBD) binds with a high affinity for ACE2. Recently, a new strain of SARS-CoV-2 has been discovered with a mutation in the S1 protein (amino acid D614 to G614) outside the RBD. Early studies provide evidence that D614G SARS-CoV-2 virus strain is likely to be more infectious and is present in the majority of current infections globally.
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