Human CellExp™ SARS-CoV-2 S1 Protein (D614G), Recombinant

Recombinant SARS-CoV-2 S1 spike protein with a mutation (D614G)
Catalog #: P1652 | abID:

Product Details

Alternate Name S1 Protein (D614G); Human CellExp™ SARS-CoV-2 S1 (D614G); Human CellExp™ SARS-CoV-2 S1 (D614G), Recombinant; SARS-CoV-2 S1 (D614G); SARS-CoV-2 S1 Protein (D614G); SARS-CoV-2 S1 Protein (D614G), Recombinant; S1 (D614G); Human CellExp™ SARS-CoV-2 S1 Protein (D614G); Human CellExp™ SARS-CoV-2 S1 (D614G)
Source HEK 293 cells
Appearance Lyophilized powder
Molecular Weight 120 kDa
Purity by SDS-PAGE > 95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino Acid Sequence Val 16 - Arg 685
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SARS-CoV-2, the causative virus of COVID-19, uses the viral Spike (S) protein for host cell attachment and entry. The virus uses multiple factors including the human protease Furin, Angiotensin converting enzyme 2 (ACE2), Neuropilin-1 (NRP1) and the transmembrane protease serine 2 (TMPRSS2) for receptor interactions. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives the membrane fusion and eventual entry of the virus. The S glycoprotein serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. Within the S1 protein, the conserved receptor-binding domain (RBD) binds with a high affinity for ACE2. Recently, a new strain of SARS-CoV-2 has been discovered with a mutation in the S1 protein (amino acid D614 to G614) outside the RBD. Early studies provide evidence that D614G SARS-CoV-2 virus strain is likely to be more infectious and is present in the majority of current infections globally.

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