Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

New

Human CellExp™ SARS-CoV-2 S1 (K417N), Recombinant

A key protein in allowing viral entry into host cells
Catalog #: P1663
SKU-Size Size Price Qty
P1663-10 10 µg
$225.00
P1663-50 50 µg
$425.00
More Sizes Get Quote

Product Details

Alternate Name S1 Protein, Spike glycoprotein subunit1, S glycoprotein subunit1, SARS-CoV-2 S1 Protein
Gene ID 43740568
Accession # P0DTC2
Source HEK 293 cells
Appearance Lyophilized protein
Physical Form Description Lyophilized powder
Molecular Weight ~120 kDa (8xHis tag at the C-terminus)
Purity by SDS-PAGE > 95%
Formulation Lyophilized from 0.22 µm filtered PBS (pH 7.4) with 5% trehalose
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SARS-CoV-2, the causative virus of COVID-19, uses the viral Spike (S) protein for host cell attachment and entry. The virus uses multiple host targets including the human protease Furin, Angiotensin converting enzyme 2 (ACE2), Neuropilin-1 (NRP1) and the transmembrane protease serine 2 (TMPRSS2) for host cell entry. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives the membrane fusion and eventual entry of the virus. The S glycoprotein serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. Within the S1 protein, the conserved receptor-binding domain (RBD) binds with a high affinity for ACE2. Recently, fast-spreading variants were identified in the UK, South Africa, and Brazil. One of those variants of SARS-CoV-2 contains the K417N mutation, which is a lysine (K) to asparagine (N) substitution at position 417 in the RBD. Epidemiologist estimated that the new variant is roughly 50% more transmissible as compared to other dominant lineages based on the rate it spreads. According to the CDC, they also claim a moderate impact on neutralization by monoclonal antibody therapeutics and convalescent/post-vaccination sera.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.