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Human CellExp™ ROR1, Rat Recombinant

Receptor for wnt ligand WNT5A
Catalog #: P1249

In stock

SKU-Size Size Price Qty
P1249-10 10 μg
$95.00
P1249-50 50 μg
$395.00
More Sizes Get Quote

Product Details

Alternate Name ROR1, NTRKR1
Gene Symbol ROR1
Gene ID 362550
Accession # EDL97819
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
Molecular Weight 43.5 kDa
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in distilled water.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.


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