Human CellExp™ ROR1, Fc Tag, Human Recombinant

Receptor for Wnt ligand WNT5A
Catalog #: P1750 | abID:

Product Details

Alternate Name Receptor Tyrosine Kinase Like Orphan Receptor 1; NTRKR1; Neurotophic Tyrosine Kinase, Receptor-Related 1
Gene ID 4919
Accession # Q01973
Source HEK 293 cells
Appearance Lyophilized protein
Physical Form Description Lyophilized powder
Molecular Weight ~69 kDa (observed due to glycosylation)
Purity by > 90% as determined by SDS-PAGE
Formulation Lyophilized from sterile PBS, pH 7.4
Endotoxin Level < 1.0 EU per μg of the protein as determined by the LAL method
Amino Acid Sequence Gln 30 to Glu 403 with C-terminal Fc of human IgG1
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.


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